Pregnancy - HH-RA.org

Bibliography Tag: pregnancy

Hashimoto et al., 2017

Hashimoto, K., Yasumura, S., Fujimori, K., Kyozuka, H., Wakaki, Y., Sato, A., Hanzawa, H., Yokoyama, T., Sato, T., & Hosoya, M.; “The Japan Environment and Children’s Study (JECS) in Fukushima Prefecture-A progress report on the enrollment stage;” Fukushima Journal of Medical Science, 2017, 63(2), 57-63; DOI: 10.5387/fms.2016-17.

ABSTRACT:

The Japan Environment and Children’s Study is an ongoing nationwide birth cohort study that is being conducted at 15 regional centers throughout Japan. The recruitment of subjects in the study area within Fukushima Prefecture, which includes Fukushima City, Minami Soma City and Futaba County, was begun on January 31, 2011 with the cooperation of the obstetrics and gynecology departments of local medical institutions. On March 11, soon after the start of recruitment, the Tohoku region was hit by an unprecedented disaster in the shape of the Great East Japan Earthquake, which was closely followed by the Tokyo Electric Power Company’s Fukushima Daiichi Nuclear Power Plant accident. As a result of the disaster, the study area in Fukushima Prefecture was expanded on October 1, 2012 to include 59 municipalities across Fukushima Prefecture. Three points are seen as particularly important: 1) Radiation risk communication, 2) The motto is “Be attentive. Be supportive.”, and 3) Establishing cooperating partnerships. With the cooperation of all concerned, the recruitment period ended on March 31, 2014. The tentative total number of the participants enrolled at the Fukushima Regional Center was 34,666 (13,134 pregnant mothers, 8,695 fathers and 12,837 children born before November 30, 2014 as of June 2016). FULL TEXT

Etzel et al., 2014

Etzel, Ruth, Charles, Marie-Aline, Dellarco, Michael, Gajeski, Katie, Jöckel, Karl-Heinz, Hirschfeld, Steven, Kamijima, Michihiro, Kawamoto, Toshihiro, Kolossa-Gehring, Marike, Nakayama, Shoji, Schmidt, Börge, Tian, Ying, Wolz, Birgit, Zaros, Cécile, & Zhang, Jun; “Harmonizing Biomarker Measurements in Longitudinal Studies of Children’s Health and the Environment;” Biomonitoring, 2014, 1(1), 50-62; DOI: 10.2478/bimo-2014-0006.

ABSTRACT:

Large scale studies of environmental influences on children’s health and development are being planned or conducted in many places, including Japan, France, Shanghai (China), the United States, and Germany. The objective of these “next generation” studies is to better understand a broad range of environmental and social factors that influence the health and well-being of children. Some of these studies are designed to enroll tens of thousands of children and follow them for many years to investigate the influence of the environment on child growth, development and health. Environment is broadly defined in these studies and includes investigation of chemical, biological, physical and socioeconomic factors. An international group composed of study teams from Japan, France, Shanghai (China), the United States, and Germany has been meeting since 2011 to exchange information and work towards harmonization of processes that would provide the opportunity to compare methods and develop procedures to conduct combined analyses of results and data pooling procedures. Harmonization of infant health outcomes, biomarkers, environmental measurements, socioeconomic and migration status has been initiated. This manuscript provides an overview of the Environment and Child Health International Birth Cohort Group and its history, describes the progress of work, and discusses the advantages of this international collaborative effort. FULL TEXT

Eguchi et al., 2017

Eguchi, A., Otake, M., Hanazato, M., Suzuki, N., Matsuno, Y., Nakaoka, H., Todaka, E., & Mori, C.; “Assessment of questionnaire-based PCB exposure focused on food frequency in birth cohorts in Japan;” Environmental Science and Pollution Research International, 2017, 24(4), 3531-3538; DOI: 10.1007/s11356-016-8119-6.

ABSTRACT:

We investigated the relationship between food frequency questionnaire (FFQ) responses and serum polychlorinated biphenyl (PCB) levels of mothers and fathers recruited from the Chiba Regional Center, which is one of the 15 regional centers of the Japan Environment and Children’s Study (mothers: n = 1477, fathers: n = 219). The expected PCB values were estimated from the participants’ FFQ answers and medical records (age, body mass index and number of deliveries). Based on the stepwise forward selection results of Bayesian regression models, age and fish and egg consumption were positively associated with PCB concentrations and a number of deliveries were negatively associated with PCB concentrations in mothers, whereas only age was positively associated with PCB concentrations in fathers.These findings indicated that the estimation of daily dietary intake may be useful for the prediction of PCB concentration for mothers. FULL TEXT

Chiu et al., 2018

Chiu, Y. H., Williams, P. L., Gillman, M. W., Gaskins, A. J., Minguez-Alarcon, L., Souter, I., Toth, T. L., Ford, J. B., Hauser, R., Chavarro, J. E., & Team, Earth Study; “Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology;” JAMA Internal Medicine, 2018, 178(1), 17-26; DOI: 10.1001/jamainternmed.2017.5038.

ABSTRACT:

IMPORTANCE:

Animal experiments suggest that ingestion of pesticide mixtures at environmentally relevant concentrations decreases the number of live-born offspring. Whether the same is true in humans is unknown. Objective: To examine the association of preconception intake of pesticide residues in fruits and vegetables (FVs) with outcomes of infertility treatment with assisted reproductive technologies (ART).

DESIGNT, SETTING, AND PARTICIPANTS:

This analysis included 325 women who completed a diet assessment and subsequently underwent 541 ART cycles in the Environment and Reproductive Health (EARTH) prospective cohort study (2007-2016) at a fertility center at a teaching hospital. We categorized FVs as having high or low pesticide residues using a validated method based on surveillance data from the US Department of Agriculture. Cluster-weighted generalized estimating equations were used to analyze associations of high- and low-pesticide residue FV intake with ART outcomes.

MAIN OUTCOMES AND MEASURES:

Adjusted probabilities of clinical pregnancy and live birth per treatment cycle.

RESULTS:

In the 325 participants (mean [SD] age, 35.1 [4.0] y; body mass index, 24.1 [4.3]), mean (SD) intakes of high- and low-pesticide residue FVs were 1.7 (1.0) and 2.8 (1.6) servings/d, respectively. Greater intake of high-pesticide residue FVs was associated with a lower probability of clinical pregnancy and live birth. Compared with women in the lowest quartile of high-pesticide FV intake (<1.0 servings/d), women in the highest quartile (>/=2.3 servings/d) had 18% (95% CI, 5%-30%) lower probability of clinical pregnancy and 26% (95% CI, 13%-37%) lower probability of live birth. Intake of low-pesticide residue FVs was not significantly related to ART outcomes.

CONCLUSIONS AND RELEVANCE:

Higher consumption of high-pesticide residue FVs was associated with lower probabilities of pregnancy and live birth following infertility treatment with ART. These data suggest that dietary pesticide exposure within the range of typical human exposure may be associated with adverse reproductive consequences. FULL TEXT

Sagiv et al., 2019

Sagiv, S. K., Bruno, J. L., Baker, J. M., Palzes, V., Kogut, K., Rauch, S., Gunier, R., Mora, A. M., Reiss, A. L., & Eskenazi, B.; “Prenatal exposure to organophosphate pesticides and functional neuroimaging in adolescents living in proximity to pesticide application;” Proceedings of the National Academy of Sciences of the United States of America, 2019; DOI: 10.1073/pnas.1903940116.

ABSTRACT:

We have reported consistent associations of prenatal organophosphate pesticide (OP) exposure with poorer cognitive function and behavior problems in our Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a birth cohort of Mexican American youth in California’s agricultural Salinas Valley. However, there is little evidence on how OPs affect neural dynamics underlying associations. We used functional near-infrared spectroscopy (fNIRS) to measure cortical activation during tasks of executive function, attention, social cognition, and language comprehension in 95 adolescent CHAMACOS participants. We estimated associations of residential proximity to OP use during pregnancy with cortical activation in frontal, temporal, and parietal regions using multiple regression models, adjusting for sociodemographic characteristics. OP exposure was associated with altered brain activation during tasks of executive function. For example, with a 10-fold increase in total OP pesticide use within 1 km of maternal residence during pregnancy, there was a bilateral decrease in brain activation in the prefrontal cortex during a cognitive flexibility task (β = -4.74; 95% CI: -8.18, -1.31 and β = -4.40; 95% CI: -7.96, -0.84 for the left and right hemispheres, respectively). We also found that prenatal OP exposure was associated with sex differences in brain activation during a language comprehension task. This first functional neuroimaging study of prenatal OP exposure suggests that pesticides may impact cortical brain activation, which could underlie previously reported OP-related associations with cognitive and behavioral function. Use of fNIRS in environmental epidemiology offers a practical alternative to neuroimaging technologies and enhances our efforts to assess the impact of chemical exposures on neurodevelopment. FULL TEXT

Curl et al., 2019

Curl, C. L., Porter, J., Penwell, I., Phinney, R., Ospina, M., & Calafat, A. M.; “Effect of a 24-week randomized trial of an organic produce intervention on pyrethroid and organophosphate pesticide exposure among pregnant women;” Environment International, 2019, 104957; DOI: 10.1016/j.envint.2019.104957.

ABSTRACT:

BACKGROUND: Introduction of an organic diet can significantly reduce exposure to some classes of pesticides in children and adults, but no long-term trials have been conducted.

OBJECTIVES: To assess the effect of a long-term (24-week) organic produce intervention on pesticide exposure among pregnant women.

METHODS: We recruited 20 women from the Idaho Women, Infants, and Children (WIC) program during their first trimester of pregnancy. Eligible women were nonsmokers aged 18-35 years who reported eating exclusively conventionally grown food. We randomly assigned participants to receive weekly deliveries of either organic or conventional fruits and vegetables throughout their second or third trimesters and collected weekly spot urine samples. Urine samples, which were pooled to represent monthly exposures, were analyzed for biomarkers of organophosphate (OP) and pyrethroid insecticides.

RESULTS: Food diary data demonstrated that 66% of all servings of fruits and vegetables consumed by participants in the “organic produce” group were organic, compared to <3% in the “conventional produce” group. We collected an average of 23 spot samples per participant (461 samples total), which were combined to yield 116 monthly composites. 3-Phenoxybenzoic acid (3-PBA, a non-specific biomarker of several pyrethroids) was detected in 75% of the composite samples, and 3-PBA concentrations were significantly higher in samples collected from women in the conventional produce group compared to the organic produce group (0.95 vs 0.27mug/L, p=0.03). Another pyrethroid biomarker, trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, was detected more frequently in women in the conventional compared to the organic produce groups (16% vs 4%, p=0.05). In contrast, we observed no statistically significant differences in detection frequency or concentrations for any of the four biomarkers of OP exposure quantified in this trial.

DISCUSSION: To our knowledge, this is the first long-term organic diet intervention study, and the first to include pregnant women. These results suggest that addition of organic produce to an individual’s diet, as compared to conventional produce, significantly reduces exposure to pyrethroid insecticides. FULL TEXT

Wenzel et al., 2018

Wenzel, A. G., Brock, J. W., Cruze, L., Newman, R. B., Unal, E. R., Wolf, B. J., Somerville, S. E., & Kucklick, J. R.; “Prevalence and predictors of phthalate exposure in pregnant women in Charleston, SC;” Chemosphere, 2018, 193, 394-402; DOI: 10.1016/j.chemosphere.2017.11.019. https://www.ncbi.nlm.nih.gov/pubmed/29154114.

ABSTRACT:

Phthalates are plasticizers commonly detected in human urine due to widespread exposure from PVC plastics, food packaging, and personal care products. Several phthalates are known antiandrogenic endocrine disruptors, which raises concern for prenatal exposure during critical windows of fetal development. While phthalate exposure is ubiquitous, certain demographics are subject to greater or lesser exposure. We sampled urine from 378 pregnant women during the second trimester of gestation living in Charleston, SC, and measured eight urinary phthalate metabolites as biomarkers of phthalate exposure: monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), and monomethyl phthalate (MMP). Demographic data was collected from questionnaires administered at the time of specimen collection. All phthalate metabolites were detected in over 93% of urine samples. On average, concentrations were highest for MEP (median = 47.0 ng/mL) and lowest for MMP (median = 1.92 ng/mL). Sociodemographic characteristics associated with elevated phthalate concentrations included being unmarried, less educated, having a low income, high body mass index (BMI), and/or being African American. After racial stratification, age, BMI, education, and income were significantly associated with phthalate concentrations in African American women. Marital status was associated with phthalate concentrations in Caucasian women only, with greater concentrations of MBP, MEHHP, MiBP, and MMP in unmarried versus married women. Results of this cross-sectional study provide evidence for significant racial and demographic variations in phthalate exposure. FULL TEXT

Aris and Leblanc, 2011

Aris, Aziz, & Leblanc, Samuel; “Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada.;” Reproductive Toxicology, 2011, 31, 528-533; DOI: 10.1016/j.reprotox.2011.02.004.

ABSTRACT:

Pesticides associated to genetically modified foods (PAGMF), are engineered to tolerate herbicides such as glyphosate (GLYP) and gluphosinate (GLUF) or insecticides such as the bacterial toxin bacillus thuringiensis (Bt). The aim of this study was to evaluate the correlation between maternal and fetal exposure, and to determine exposure levels of GLYP and its metabolite aminomethyl phosphoric acid (AMPA), GLUF and its metabolite 3-methylphosphinicopropionic acid (3-MPPA) and Cry1Ab protein (a Bt toxin) in Eastern Townships of Quebec, Canada. Blood of thirty pregnant women (PW) and thirty-nine nonpregnant women (NPW) were studied. Serum GLYP and GLUF were detected in NPW and not detected in PW. Serum 3-MPPA and CryAb1 toxin were detected in PW, their fetuses and NPW. This is the first study to reveal the presence of circulating PAGMF in women with and without pregnancy, paving the way for a new field in reproductive toxicology including nutrition and utero-placental toxicities. FULL TEXT

Beuret et al., 2005

Beuret, Cecilia Judith, Zirulnik, Fanny, & Giménez, María Sofía; “Effect of the herbicide glyphosate on liver lipoperoxidation in pregnant rats and their fetuses;” Reproductive Toxicology, 2005, 19(4), 501-504; DOI: 10.1016/j.reprotox.2004.09.009.

ABSTRACT:

Glyphosate is a post-emergence herbicide that acts on the synthesis of amino acids and other endogenous metabolites in plants. It is commonly used in agriculture, forestry, and nurseries for the control or destruction of herbaceous plants. Metabolic processes during development and pregnancy could be sensitive to changes induced by glyphosate such as lipid peroxidation. The present study has investigated the effects that 1% glyphosate oral exposure has on lipoperoxidation and antioxidant enzyme systems in the maternal serum and liver of pregnant rats and their term fetuses at 21 days of gestation. The results suggest that excessive lipid peroxidation induced with glyphosate ingestion leads to an overload of maternal and fetal antioxidant defense systems.

Gallegos et al., 2016

Gallegos, Cristina E., Bartos, Mariana, Bras, Cristina, Gumilar, Fernanda, Antonelli, Marta C., & Minetti, Alejandra; “Exposure to a glyphosate-based herbicide during pregnancy and lactation induces neurobehavioral alterations in rat offspring;” NeuroToxicology, 2016, 53, 20-28; DOI: 10.1016/j.neuro.2015.11.015.

ABSTRACT:

The impact of sub-lethal doses of herbicides on human health and the environment is a matter of controversy. Due to the fact that evidence particularly of the effects of glyphosate on the central nervous system of rat offspring by in utero exposure is scarce, the purpose of the present study was to assess the neurobehavioral effects of chronic exposure to a glyphosate-containing herbicide during pregnancy and lactation. To this end, pregnant Wistar rats were exposed through drinking water to 0.2% or 0.4% of a commercial formulation of glyphosate (corresponding to a concentration of 0.65 or 1.30g/L of glyphosate, respectively) during pregnancy and lactation and neurobehavioral alterations in offspring were analyzed. The postnatal day on which each pup acquired neonatal reflexes (righting, cliff aversion and negative geotaxis) and that on which eyes and auditory canals were fully opened were recorded for the assessment of sensorimotor development. Locomotor activity and anxiety levels were monitored via open field test and plus maze test, respectively, in 45- and 90-day-old offspring. Pups exposed to a glyphosate-based herbicide showed early onset of cliff aversion reflex and early auditory canal opening. A decrease in locomotor activity and in anxiety levels was also observed in the groups exposed to a glyphosate-containing herbicide. Findings from the present study reveal that early exposure to a glyphosate-based herbicide affects the central nervous system in rat offspring probably by altering mechanisms or neurotransmitter systems that regulate locomotor activity and anxiety.

Bibliography Index